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Jelena Kolic, James D. Johnson  Cell Metabolism 

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1 Specialized Hub Beta Cells Trade Maximal Insulin Production for Perfect Timing 
Jelena Kolic, James D. Johnson  Cell Metabolism  Volume 24, Issue 3, Pages (September 2016) DOI: /j.cmet Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Hub Beta Cells Set the Pace for Synchronized Beta Cell Work
Hub cells have more glucokinase (Gck) but less insulin, possibly due to the lower expression of the key transcription factors Pdx1 and Nkx6.1. Hubs serve to set the islet’s pace, likely in response to neuronal stimulation. Follower cells produce more insulin and are connected to each other via gap junctions. Rowing image courtesy of Wikimedia Commons. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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