1. Lissencephaly Introduction Classified as disorders of neuronal migration Congenital disorder that arises due to brain malformation that is characterized by reduction in gyri and sulci, thickening, and impairment of cerebral cortex Arises due to a halt in neuronal migration prior to 4 th gestational month Mochida, G. H. (2009). Genetics and biology of microcephaly and lissencephaly. Seminars in pediatric neurology, 16(3), p. 120-126.

2. Types of Lissencephaly TYPE 1 LISSENCEPHALY Also known as classic lissencephaly Thickened cerebral cortex and impaired Integrity of pial surface is not affected TYPE 2 LISSENCEPHALY Also known as cobblestone complex Cobblestone like nodules on the brain due to over migration of cortical neurons Integrity of pial surface affected

3. Types of Lissencephaly TYPE 1 LISSENCEPHALYTYPE 2 LISSENCEPHALY Tortori-Donati, P., & Rossi, A. (n.d.). Congenital malformations in the neonate. Retrieved from http://www.mrineonatalbrain.com/ch04-11.php#cont-5

4. Symptoms Difficulty feeding Failure to thrive Intellectual impairment Malformed fingers, toes, or hands Muscle spasms Psychomotor impairment Seizures Trouble swallowing