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Going Forward with Retromer

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1 Going Forward with Retromer
Ginny G. Farias, David C. Gershlick, Juan S. Bonifacino  Developmental Cell  Volume 29, Issue 1, Pages 3-4 (April 2014) DOI: /j.devcel Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 The Role of Retromer in Neurons
Left: Simplified view of endosomal trafficking pathways throughout the cell. The classical retromer pathway can be seen from the endosome to the TGN, as well as the more recently described pathway from the endosome to the plasma membrane. Retromer tubules are shown in green. Center: Structure and domains of a neuron. Right: Model of dendritic receptor delivery to plasma membrane by retromer. β2ARs (blue) are delivered to and function at the shaft, whereas neurotransmitter receptors such as AMPA- or NMDA-type glutamate receptors (red) function at the spine. Retromer tubules are shown in green. Developmental Cell  , 3-4DOI: ( /j.devcel ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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