1. Treatment-Resistant Schizophrenia

3. Schizophrenia

4. Treatment-Resistant Schizophrenia

5. Definition of TRS TRRIP Working Group Consensus

6. Pathophysiology of TRS

7. Economic Burden of TRS Healthcare Expenditures

8. Clinical Burden of TRS

9. Diagnosis of TRS Clinical Considerations

10. Diagnosis of TRS Definitions of Adequate Treatment and Response

11. Therapeutic Drug Monitoring

12. Long-Acting Injectables

13. Addressing Medication Adherence

14. Assessing Severity of Schizophrenia Symptoms

15. Using Symptom Severity Scales in the Clinic

16. Team Approach to Managing Schizophrenia

17. Assessing the Patient With TRS

18. Clozapine in Patients With TRS

19. Underuse of Clozapine in Patients With TRS

20. Maximizing Benefit From Clozapine

21. New Therapeutic Approaches in Development

22. Challenges of Drug Development in TRS Disease Heterogeneity

23. Challenges of Drug Development in TRS Trial Design

24. Managing TRS in the Clinic

25. Conclusions

26. Abbreviations