1. Practical Challenges in Obesity: Is It Possible to Maintain Weight Loss?

3. Introduction/Overview

4. The Obesogenic Environment

5. The Ready Availability of Foods That Promote Obesity

6. Epigenetic Changes: Causes or Consequences of Obesity?

7. "Fidgeting“* Can Inhibit Weight Gain (at Least in Some Individuals)

8. Gut Microbiota and Obesity

9. The Conversation: Finding Out Why a Patient Overeats May Help to Target the Treatment

10. Mechanisms of Food Intake Regulation

11. Gut Hormone Changes Persistently Oppose Diet-Induced Weight Loss

12. Fat Deposition May Be Determinative of Cardiometabolically Risky Obesity

13. Obesity as a Risk Factor for (and Multiplier of) a Range of Comorbid Conditions

14. Weight Loss Is a Challenge Because, Physiologically, It Is Perceived as a Dysfunction

15. Obesity: Imbalance of Energy Regulation

16. Factors Associated With Long-Term Weight Loss Maintenance

17. “The Biggest Loser” and the Persistence of Metabolic Adaptation

18. Obesity Is a Serious Disease; It Needs to Be Treated Like a Serious Disease

19. Characteristics of More and Less Successful Weight Loss Losers After Bariatric Surgery

20. Weight Loss With Orlistat: 2 Years’ Data

21. Weight Loss With Naltrexone/Bupropion: 78 Weeks

22. Early Treatment Response and Stopping Rules

23. SCALE Maintenance: Proportion of Patients Maintaining Run-In Weight Loss or Regaining ≥ 5% From Randomization to Week 56

24. Real-World Clinical Effectiveness of Liraglutide 3.0 mg

25. Summary and Conclusions

26. Abbreviations

27. Abbreviations (cont)