1. Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia 
Crystal Aguh, MD, Yemisi Dina, BS, C. Conover Talbot, BS, Luis Garza, MD, PhD 
Journal of the American Academy of Dermatology 
Volume 79, Issue 5, Pages e1 (November 2018)
DOI: /j.jaad
Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

2. Fig 1
A total of 21,000 genes were analyzed via microarray analysis. Fibroproliferative genes of interest are highlighted. Up-regulated genes (>2 standard deviations [SDs]) are noted in red, unchanged genes (<2 SDs) are noted in gray, and down-regulated genes are noted in blue. CCCA, Central centrifugal cicatricial alopecia; COL1A1, collagen type I alpha 1 chain gene; COL1A2, collagen type II alpha 1 chain gene; COL3A1, collagen type III alpha 1 chain gene; COL5A1, collagen type V alpha 1 chain gene; COL5A2, collagen type V alpha 2 chain gene; Ctrl, control; FAP, fibroblast activation protein alpha gene; FC, fold change; FN1, fibronectin 1 gene; IGF1, insulin-like growth factor 1gene; MMP1, matrix metallopeptidase 1 gene; MMP2, matrix metallopeptidase 2 gene; MMP7, matrix metallopeptidase 7 gene; MMP8, matrix metallopeptidase 8 gene; MMP9, matrix metallopeptidase 9 gene; PDGFRA, platelet derived growth factor receptor alpha gene; PDGFRB, platelet derived growth factor receptor beta gene; Pt, patient; TGFB1, transforming growth factor beta 1 gene; TGFB2, transforming growth factor beta 2 gene; VEGFA, vascular endothelial growth factor A gene; VEGFB, vascular endothelial growth factor B gene.
Journal of the American Academy of Dermatology  , e1DOI: ( /j.jaad )
Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

3. Supplemental Fig 1
Ingenuity pathway analysis of losartan potassium (A), lovastatin (B), and atorvastatin (C) as potential therapeutic targets of central centrifugal cicatricial alopecia (CCCA). Predicted inhibitory relationships of each drug are denoted by a dotted line with a flat end, whereas predicted activating relationships are denoted by a dotted line ending in an arrowhead. Up-regulated genes in our data set are highlighted in dark red (6 standard deviations [SDs]) or light red (3 SDs), whereas down-regulated targets are highlighted in dark blue (6 SDs) or light blue (3 SDs). The log fold change in expression is denoted under each gene. ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1 gene; AGTR1, angiotensin II receptor type 1 gene; APOE, apolipoprotein E gene; ATF3, ADP ribosylation factor 3 gene; CACNA1C, calcium voltage-gated channel auxiliary subunit alpha1 C gene; COL1A1, collagen type I alpha 1 chain gene; COL3A1, collagen type III alpha 1 chain gene; COTL1, coactosin like F-actin binding protein 1 gene; CRP, C-reactive protein gene; DISP1, dispatched RND transporter family member 1 gene; EDNRA, endothelin receptor type A gene; EGFR1, epidermal growth factor receptor 1 gene; FN1, fibronectin 1 gene; FOS, Fos proto-oncogene, AP-1 transcription factor subunit gene; FOSB, FosB proto-oncogene, AP-1 transcription factor subunit gene; HBA1, hemoglobin subunit alpha 1 gene; HBA2, hemoglobin subunit alpha 2 gene; HBB, hemoglobin subunit beta gene; IDI1, isopentenyl-diphosphate delta isomerase 1 gene; IL6, interleukin 6 gene; JUN, Jun proto-oncogene, AP-1 transcription factor subunit gene; MMP2, matrix metallopeptidase 2 gene; MMP9, matrix metallopeptidase 9 gene; MSMO1, methylsterol monooxygenase 1 gene; POSTN, periostin gene; PTH1R, parathyroid hormone 1 receptor gene; RGS1, regulator of G-protein signaling 1 gene; S100A12, S100 calcium binding A12 gene; SERPINE1, serpin family E member 1 gene; TGFB2, transforming growth factor beta 2 gene; ZNF682, zinc finger protein 682 gene.
Journal of the American Academy of Dermatology  , e1DOI: ( /j.jaad )
Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions