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L. -W. Song, P. -G. Liu, C. -J. Liu, T. -Y. Zhang, X. -D. Cheng, H. -L

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Presentation on theme: "L. -W. Song, P. -G. Liu, C. -J. Liu, T. -Y. Zhang, X. -D. Cheng, H. -L"— Presentation transcript:

1 Quantitative hepatitis B core antibody levels in the natural history of hepatitis B virus infection 
L.-W. Song, P.-G. Liu, C.-J. Liu, T.-Y. Zhang, X.-D. Cheng, H.-L. Wu, H.-C. Yang, X.-K. Hao, Q. Yuan, J. Zhang, J.-H. Kao, D.-S. Chen, P.-J. Chen, N.-S. Xia  Clinical Microbiology and Infection  Volume 21, Issue 2, Pages (February 2015) DOI: /j.cmi Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

2 FIG. 1 Distribution of serum anti-HBc levels during different phases of HBV infection. (a) Distribution of serum anti-HBc levels during different phases of HBV infection. Bars represent the mean with a 95% confidence interval. PBI, past hepatitis B virus infection (n = 535); OBI, occult HBV infection (n = 56); IT, immune tolerance phase (n = 108); IC, immune clearance phase (n = 209); LR, low-replicative phase (n = 148); ENH, HBeAg-negative hepatitis phase (n = 133). Receiver operating characteristic analyses of the qAnti-HBc to differentiate (b) HBsAg-positive individuals among all anti-HBc-positive subjects and (c) OBI individuals among HBsAg subjects. Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

3 FIG. 2 Association between the levels of anti-HBc and ALT in CHB subjects. (a) Average serum anti-HBc levels of CHB subjects according to the ALT stratum. (b) ROC analysis of the anti-HBc level to discriminate ALT elevation (greater than the upper limit of normal) in CHB subjects. HBc, hepatitis B core protein; ALT, alanine aminotransferase; CHB, chronic hepatitis B; ROC, receiver operating characteristic curve; AUROC, area under the ROC curve. Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

4 FIG. 3 Correlation between the qAnti-HBc level and ALT, AST and HBV DNA, and HBsAg in subjects in various infection phases. (a) IT phase. (b) IC phase. (c) LR phase. (d) ENH phase. qAnti-HBc, quantitative anti–hepatitis B core protein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; IT, immune tolerance phase; IC, immune clearance phase; LR, low-replicative phase; ENH, HBeAg-negative hepatitis phase. Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

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