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Component-resolved diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteins∗  Ingrid Sander, PhD, Hans-Peter Rihs, PhD,

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Presentation on theme: "Component-resolved diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteins∗  Ingrid Sander, PhD, Hans-Peter Rihs, PhD,"— Presentation transcript:

1 Component-resolved diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteins∗  Ingrid Sander, PhD, Hans-Peter Rihs, PhD, Gert Doekes, PhD, Santiago Quirce, MD, Esmeralda Krop, PhD, Peter Rozynek, MSc, Vera van Kampen, PhD, Rolf Merget, MD, Ursula Meurer, Thomas Brüning, MD, Monika Raulf, PhD  Journal of Allergy and Clinical Immunology  Volume 135, Issue 6, Pages (June 2015) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Total IgE and sIgE concentrations to grass pollen (gx1), wheat flour (f4), and rye flour (f5) of the study groups of 101 bakers and 29 control subjects. The median values of bakers (solid lines) and control subjects (dashed lines) and cutoff values (dotted lines) for sIgE (≥0.35 kUA/L) and total IgE (>100 kUA/L) are indicated. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 sIgE concentrations of 0.1 kUA/L or greater in sera of bakers and control subjects to recombinant wheat allergens and the CCDs HRP and MUXF measured by using CAP-FEIA. The solid line marks the usual cutoff for positive values, and the dashed lines indicate the limits between the different CAP classes (class 1, ≥ kUA/L; class 2, kUA/L; class 3, kUA/L; class 4, kUA/L; and class 5, kUA/L). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Inhibition of sIgE binding to single allergens by wheat flour, rye flour, or grass pollen proteins. Each bar indicates the mean and SD of the inhibition percentage obtained with 2 bakers' sera from different countries. Three sera for Tri a 39 and only 1 serum for Tri a 35 and the peroxidase were used, and in the case of Tri a 19, the second serum was a control serum. Inhibition greater than 20% is evaluated as significant. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 sIgE concentrations to wheat flour in relation to the sum of sIgE concentrations to single allergens. The solid lines at 0.35 kUA/L mark the usual cutoff for positive values. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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