1. Osteoarthritis in a dish: the effects of pro-inflammatory cytokines on cartilage derived from induced pluripotent stem cells 
V.P. Willard, B.O. Diekman, J. Sanchez-Adams, S.K. O'Connor, N. Christoforou, K.W. Leong, F. Guilak 
Osteoarthritis and Cartilage 
Volume 21, Pages S281-S282 (April 2013)
DOI: /j.joca
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2. Figure 1
Release of MMPs and GAGs from iPSC-derive cartilage in an in vitro model of OA. (A) All three IL-1α doses resulted in a significant increase in MMP release from iPSC neocartilage. (B) IL-1 α doses above 100 pg/ml resulted in an increased loss of GAG from the pellets and into the media. Groups not connected by the same letter as statistically different with P < 0.05, Mean ± SEM.
Osteoarthritis and Cartilage  , S281-S282DOI: ( /j.joca )
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3. Figure 2
IL-1α induced degeneration of iPSC neocartilage. (A) Safranin-0 staining confirmed GAG loss from iPSC pellets at high IL-1α doses (positive staining is red, scale bar = 100 μm). (B) The compressive stiffness of iPSC-derived cartilage significantly decreased following IL-1α treatments above 100 pg/ml. Groups not connected by the same letter as statistically different with P < Mean ±SEM.
Osteoarthritis and Cartilage  , S281-S282DOI: ( /j.joca )
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