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RGFP-966 increases H4K12 acetylation in HEK/APPsw cells.

Published byЈасна Секулић Modified over 6 years ago

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Presentation on theme: "RGFP-966 increases H4K12 acetylation in HEK/APPsw cells."— Presentation transcript:

1 RGFP-966 increases H4K12 acetylation in HEK/APPsw cells.
RGFP-966 increases H4K12 acetylation in HEK/APPsw cells. (A) RGFP-966 increased histone H4K12 acetylation (H4K12ac) in a time-dependent manner. A significant increase in H4K12ac was observed following 6, 24, and 48 h of treatment with 10 μM RGFP-966. (B) H4K12ac ELISA revealed 7.96 ± 1.81 ng/μL increase in H4K12ac following 48 h of RGFP-966 treatment. (C) H3K4, H3K27, and K4K16 acetylation increased significantly after 48 h of 10-μM RGFP-966 treatment. ANOVA with Dunnett’s multiple-comparisons test and two-tailed unpaired t-test was used for analysis. The graphs represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.001; n = 4. Karolina J. Janczura et al. PNAS 2018;115:47:E11148-E11157 ©2018 by National Academy of Sciences

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