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Metabolic Networks of Longevity

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Presentation on theme: "Metabolic Networks of Longevity"— Presentation transcript:

1 Metabolic Networks of Longevity
Riekelt H. Houtkooper, Robert W. Williams, Johan Auwerx  Cell  Volume 142, Issue 1, Pages 9-14 (July 2010) DOI: /j.cell Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 A Metabolic Network of Aging
This simplified scheme shows metabolic proteins that are involved in longevity. There are complex interactions among individual metabolic signaling pathways, such as the insulin/IGF1, TOR, AMPK, sirtuin, and FOXO pathways. These interactions impact health span and longevity. For instance, the TOR pathway, which is activated during nutrient excess, is linked not only to other nutrient-responsive pathways, such as the insulin/IGF1 pathway, but also to the CR-induced pathway involving AMPK and Foxa activation. Longevity-promoting proteins are in green, proteins that increase longevity when mutated are in orange, and other proteins are indicated in blue; mammalian protein names are used. Cell  , 9-14DOI: ( /j.cell ) Copyright © 2010 Elsevier Inc. Terms and Conditions

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