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High Expression of Zinc-Binding Protein-89 Predicts Decreased Survival in Esophageal Squamous Cell Cancer  Shu-Mei Yan, MD, Hui-Ni Wu, MB, Fan He, MD,

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Presentation on theme: "High Expression of Zinc-Binding Protein-89 Predicts Decreased Survival in Esophageal Squamous Cell Cancer  Shu-Mei Yan, MD, Hui-Ni Wu, MB, Fan He, MD,"— Presentation transcript:

1 High Expression of Zinc-Binding Protein-89 Predicts Decreased Survival in Esophageal Squamous Cell Cancer  Shu-Mei Yan, MD, Hui-Ni Wu, MB, Fan He, MD, Xiao-peng Hu, BDS, Zhi-yi Zhang, MD, Ma-Yan Huang, MD, Xiao Wu, MD, Chun-yu Huang, MD, Yong Li, MD  The Annals of Thoracic Surgery  Volume 97, Issue 6, Pages (June 2014) DOI: /j.athoracsur Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Zinc-binding protein-89 (ZBP-89) expression by immunohistochemical staining (3, 3-diaminobenzidine [DAB] solution). (A, B) Low expression of ZBP-89 protein in the nuclei of normal human esophageal cells (magnification: A,×200; B,×400). (C, D) High expression of ZBP-89 protein in the nuclei of esophageal squamous cell carcinoma (magnification: C, ×200; D, ×400). (E, F) A + expression level of ZBP-89 in esophageal squamous cell carcinoma (magnification: E, ×200; F, ×400). (G, H) A ++ expression level of ZBP-89 in esophageal squamous cell carcinoma (magnification: G, ×200; H, ×400). (I, J) A +++ expression level of ZBP-89 in esophageal squamous cell carcinoma (magnification: I, ×200; J, ×400). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Receiver operating curve for zinc-binding protein-89 (ZBP-89) expression cutoff value was plotted by survival status. (AUC = area under the curve; IRS = immunoreactivity score.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Survival analysis for esophageal squamous cell carcinoma patients according to their zinc-binding protein-89 (ZBP-89) expression. Probability of overall survival of (A) total esophageal squamous cell carcinoma patients and (B) patients with low (blue line) and high (green line) expression levels of zinc-binding protein-89. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 (A) Survival analysis of zinc-binding protein-89 (ZBP-89) expression for esophageal squamous cell carcinoma patients in TNM stage I and stage II group. (B) Survival analysis of zinc-binding protein-89 expression for esophageal squamous cell carcinoma patients in lymph node metastasis–negative group. (blue line = low expression of ZBP-89; green line = high expression of ZBP-89.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

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