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Crashpilot Underachieves due to Acetylation at the Nerve Terminal

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Presentation on theme: "Crashpilot Underachieves due to Acetylation at the Nerve Terminal"— Presentation transcript:

1 Crashpilot Underachieves due to Acetylation at the Nerve Terminal
Ruud F. Toonen, Matthijs Verhage  Neuron  Volume 72, Issue 5, Pages (December 2011) DOI: /j.neuron Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Lysine Acetylation and Deacetylation in the Nucleus and at the Synaptic Terminal (A) Histone (green) acetylation (Ac) by histone acetylases (HATs) reduces DNA (blue) binding and promotes transcription. Deacetylation by histone deacetylases (HDACs) typically represses transcription. (B) ELP3-dependent acetylation of Bruchpilot (BRP, green) controls the structure of synaptic T bars and hinders tethering of synaptic vesicles (yellow). (C) Typical electron micrographs of T bar structure in control and elp3 mutants. Arrowheads indicate T bar lengths. Scale bar represents 200 nm. Images by K. Miśkiewicz were kindly provided by P. Verstreken. We thank Tina Marquardt-Kunit for the artwork. Neuron  , DOI: ( /j.neuron ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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