1. Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure

2. Heart Failure

3. Traditional Treatment for Acute Decompensated Heart Failure

4. Traditional Treatment for Acute Decompensated Heart Failure (cont)

5. Traditional Treatment for Acute Decompensated Heart Failure (cont)

6. Traditional Positive Inotropic Agents

7. Omecamtiv Mecarbil: A Novel Selective Cardiac Myosin Activator

8. Omecamtiv Mecarbil

9. Omecamtiv Mecarbil: Echocardiogram Changes in Healthy Volunteers

10. Omecamtiv Mecarbil: Echocardiographic Changes in Patients With Stable Heart Failure and LV Dysfunction

11. ATOMIC-AHF: Study Design Randomized, Double-blind, Placebo-controlled, Sequential Cohort Study

12. ATOMIC-AHF-Primary End Point: Dyspnea Response Paired Placebo

13. Safety Concerns

14. Supraventricular and Ventricular Tachyarrhythmias

15. COSMIC-HF: Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure

16. References

17. Abbreviations

18. Abbreviations (cont)