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Published byPeter Reed Modified over 6 years ago
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Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies
Kumar Sharma, Ljiljana Paša-Tolić Kidney International Volume 93, Issue 6, Pages (June 2018) DOI: /j.kint Copyright © 2018 International Society of Nephrology Terms and Conditions
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Figure 1 Adjacent glomeruli with a seemingly normal glomerulus next to a glomerulus with focal sclerosis (arrows). To optimize viewing of this image, please see the online version of this article at Kidney International , DOI: ( /j.kint ) Copyright © 2018 International Society of Nephrology Terms and Conditions
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Figure 2 (a) Schematic modeling of the use of single-pot solid-phase-enhanced sample preparation analysis of individual glomeruli by liquid chromatography mass spectrometry (LC/MS) proteomics to identify intra- and intermouse heterogeneity in glomerular protein expression. (b) The authors found that increased LAMP1 expression is a common feature of damaged glomeruli and tubules in several patients and mouse-disease models. FSGS, focal segmental glomerulosclerosis; MCD, minimal change disease. Kidney International , DOI: ( /j.kint ) Copyright © 2018 International Society of Nephrology Terms and Conditions
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