Presentation is loading. Please wait.

Presentation is loading. Please wait.

Matrix metalloproteinase 2 is suppressed by trapidil, a CD40–CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall  Hirotaka Nagashima,

Published byNevenka Kranjc Modified over 6 years ago

Similar presentations

Presentation on theme: "Matrix metalloproteinase 2 is suppressed by trapidil, a CD40–CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall  Hirotaka Nagashima,"— Presentation transcript:

1 Matrix metalloproteinase 2 is suppressed by trapidil, a CD40–CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall  Hirotaka Nagashima, MD, PhD, Yoshikazu Aoka, MD, Yasunari Sakomura, MD, PhD, Kenta Uto, MD, Akiko Sakuta, MD, Shigeyuki Aomi, MD, PhD, Hiromi Kurosawa, MD, PhD, Nobuhisa Hagiwara, MD, PhD, Masatoshi Kawana, MD, PhD, Hiroshi Kasanuki, MD, PhD  Journal of Vascular Surgery  Volume 39, Issue 2, Pages (February 2004) DOI: /j.jvs

2 Fig 1 Trapidil significantly reduced the levels of active MMP-2 in a concentration-dependent manner in organ cultures (A) but did not alter that of MMP-9 (B). Value of the trend test, P < .001. Journal of Vascular Surgery  , DOI: ( /j.jvs )

3 Fig 2 Effect of trapidil (10 μmol/L), anti-CD154 (100 μmol/L), or aspirin (10 μmol/L) on active MMP-2 production in AAA tissues. Both trapidil and anti-CD154 antibody inhibited MMP-2 production. *P < .01 vs lane 1. Journal of Vascular Surgery  , DOI: ( /j.jvs )

4 Fig 3 Representative pattern of semiquantitative RT-PCR for MMP-2 and MMP-9. Trapidil suppressed MMP-2 mRNA expression but not MMP-9 mRNA expression. Journal of Vascular Surgery  , DOI: ( /j.jvs )

5 Fig 4 Immunohistochemical analysis. A, Hematoxylin and eosin staining. AAA tissue contains numerous inflammatory cells (magnification, 40×). B, MMP-2 is positive on macrophages (magnification, 400×). C and D, MMP-9 is produced by macrophages, a lot of neutrophils circulating in blood vessels, or neutrophils infiltrating into the aortic wall tissue (magnification, 400×). Journal of Vascular Surgery  , DOI: ( /j.jvs )

6 Fig 5 Immunostaining for CD40. A, Low magnification (40×). B, High magnification (400×). CD40 was expressed on B cells, T cells, and macrophages. Neutrophils did not express CD40. Journal of Vascular Surgery  , DOI: ( /j.jvs )

7 Fig 6 Schematic hypothesis for the inhibitory effect of trapidil on AAA formation and progression. Journal of Vascular Surgery  , DOI: ( /j.jvs )

Download ppt "Matrix metalloproteinase 2 is suppressed by trapidil, a CD40–CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall  Hirotaka Nagashima,"

Similar presentations

Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects  Hirotsugu Kurobe, MD, PhD, Yuki Matsuoka,

Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects  Hirotsugu Kurobe, MD, PhD, Yuki Matsuoka,
Mesenchymal stem cells attenuate angiotensin II-induced aortic aneurysm growth in apolipoprotein E-deficient mice  Ryotaro Hashizume, MD, Aika Yamawaki-Ogata,

Mesenchymal stem cells attenuate angiotensin II-induced aortic aneurysm growth in apolipoprotein E-deficient mice  Ryotaro Hashizume, MD, Aika Yamawaki-Ogata,
Robert J. Pitsch, MD, David J. Minion, MD, Margaret L

Robert J. Pitsch, MD, David J. Minion, MD, Margaret L
Endogenous superoxide dismutase activation by oral administration of riboflavin reduces abdominal aortic aneurysm formation in rats  Zhenhai Yu, MD, Keisuke.

Endogenous superoxide dismutase activation by oral administration of riboflavin reduces abdominal aortic aneurysm formation in rats  Zhenhai Yu, MD, Keisuke.
Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic.

Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic.
Transglutaminase type 2 in human abdominal aortic aneurysm is a potential factor in the stabilization of extracellular matrix  Sung Shin, MD, Yong-Pil.

Transglutaminase type 2 in human abdominal aortic aneurysm is a potential factor in the stabilization of extracellular matrix  Sung Shin, MD, Yong-Pil.
Age-related trends in utilization and outcome of open and endovascular repair for abdominal aortic aneurysm in the United States, 2001-2006  Margaret.

Age-related trends in utilization and outcome of open and endovascular repair for abdominal aortic aneurysm in the United States,   Margaret.
Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic.

Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic.
Popliteal artery aneurysms differ from abdominal aortic aneurysms in cellular topography and inflammatory markers  Rob Hurks, MD, PhD, Rogier H.J. Kropman,

Popliteal artery aneurysms differ from abdominal aortic aneurysms in cellular topography and inflammatory markers  Rob Hurks, MD, PhD, Rogier H.J. Kropman,
Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model  Jianping Dai, MD, PhD, Liliane.

Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model  Jianping Dai, MD, PhD, Liliane.
Markers of instability in high-risk carotid plaques are reduced by statins  Hagen Kunte, MD, Nicola Amberger, MD, Markus Alexander Busch, MD, MPH, Ralph-Ingo.

Markers of instability in high-risk carotid plaques are reduced by statins  Hagen Kunte, MD, Nicola Amberger, MD, Markus Alexander Busch, MD, MPH, Ralph-Ingo.
Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content  Hazem Abdul-Hussien, MD, Roeland Hanemaaijer,

Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content  Hazem Abdul-Hussien, MD, Roeland Hanemaaijer,
Controlled release of ascorbic acid from gelatin hydrogel attenuates abdominal aortic aneurysm formation in rat experimental abdominal aortic aneurysm.

Controlled release of ascorbic acid from gelatin hydrogel attenuates abdominal aortic aneurysm formation in rat experimental abdominal aortic aneurysm.
Karen M. Newman, PhD, Jessie Jean-Claude, MD, Hong Li, MS, John V

Karen M. Newman, PhD, Jessie Jean-Claude, MD, Hong Li, MS, John V
Veysel Kutay, MD, Cevat Yakut, MD, Hasan Ekim, MD 

Veysel Kutay, MD, Cevat Yakut, MD, Hasan Ekim, MD 
Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats 

Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats 
Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats  Keisuke Morimoto, MD, Tomomi Hasegawa,

Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats  Keisuke Morimoto, MD, Tomomi Hasegawa,
Inducible nitric oxide synthase is present in human abdominal aortic aneurysm and promotes oxidative vascular injury  Jian Zhang, MD, Jan Schmidt, MD,

Inducible nitric oxide synthase is present in human abdominal aortic aneurysm and promotes oxidative vascular injury  Jian Zhang, MD, Jan Schmidt, MD,
A decade of change in abdominal aortic aneurysm repair in the United States: Have we improved outcomes equally between men and women?  Ellen D. Dillavou,

A decade of change in abdominal aortic aneurysm repair in the United States: Have we improved outcomes equally between men and women?  Ellen D. Dillavou,
In situ localization and quantification of seventy-two – kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta  William D. McMillan,

In situ localization and quantification of seventy-two – kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta  William D. McMillan,

Similar presentations

Ads by Google