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Advances in radiation oncology
Srinivasan Vijayakumar, MD, Samuel Hellman, MD The Lancet Volume 349, Pages S1-S3 (May 1997) DOI: /S (97) Copyright © 1997 Elsevier Ltd Terms and Conditions
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Figure Dose-effect curves for radiotherapy
A=sigmoid relation of dose to tumour-control probability and B=probability of complications with conventional radiotherapy. By limiting normal tissue within radiation fields with conformal radiation therapy, curve B can be pushed to right (C), thus enabling delivery of higher dose and leading to higher cure rate with same complication rate. Vertical line 1=probabilities of cure and critical normal-tissue complications for conventional radiation therapy; vertical line 2=same for conformal radiation therapy. If choice is to use conventional dose and conformal radiation therapy, then toxicity is reduced for same cure rate (arrow, intersection of line 1 and curve C). The Lancet , S1-S3DOI: ( /S (97) ) Copyright © 1997 Elsevier Ltd Terms and Conditions
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