1. Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays 
P. Lorenzo, A. Aspberg, T. Saxne, P. Önnerfjord 
Osteoarthritis and Cartilage 
Volume 25, Issue 9, Pages (September 2017)
DOI: /j.joca
Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
Dose–response standard curve for A) Total COMP and B) COMP neoepitope-S77. Standard curves display RLUs. Inserted graph in A shows the Total COMP assay with the recombinant pentameric COMP (molecular mass 524 kDa; Image 1) and with the recombinant fragment of COMP (theoretical molecular mass pentameric structure 32 kDa; Image 2). Inserted graph in B shows the COMP neoepitope-S77 assay with the recombinant pentameric COMP (Image 1) and with the recombinant fragment of COMP (Image 2). A cartoon showing the location of the antibodies in the assays is shown.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

3. Fig. 2
Synovial fluids from patients with joint diseases were measured for A) Total COMP assay and B) COMP neoepitope-S77 assay. C) Molar ratio COMP neoepitope-S77/Total COMP. Results shown are scatter plots of Total COMP and COMP neoepitope-S77 concentrations (log scale). Boxes represent the median and quartiles, whiskers the tenth and ninetieth percentiles. Significance values were obtained using log-transformed data by ANCOVA allowing adjustment for gender and age (differences were considered significant if P < 0.05). ReA (reactive arthritis, n = 18), RA (rheumatoid arthritis, n = 23), OA (osteoarthritis, n = 22), AT (acute trauma, n = 23).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

4. Fig. 3
Molar ratio COMP neoepitope-S77/Total COMP analysis of measurement in synovial fluid from two patient groups with RA at different progression of joint destruction: RA0 no progression (Larsen grade 0–1); RA1 progression (joint replacement). Result shown is scatter plots of the ratio the values COMP neoepitope-S77/Total COMP (log scale). Boxes represent the median and quartiles, whiskers the tenth and ninetieth percentiles. Inserted table shows the median (25th–75th quartile). P values were obtained from the Mann–Whitney U test for group comparison (differences were considered significant if P < 0.05).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions