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Stability of admixture containing morphine sulfate, bupivacaine hydrochloride, and clonidine hydrochloride in an implantable infusion system  Ashley M.

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Presentation on theme: "Stability of admixture containing morphine sulfate, bupivacaine hydrochloride, and clonidine hydrochloride in an implantable infusion system  Ashley M."— Presentation transcript:

1 Stability of admixture containing morphine sulfate, bupivacaine hydrochloride, and clonidine hydrochloride in an implantable infusion system  Ashley M. Classen, DO, FAOCA, Gary H. Wimbish, PhD, DABFT, Thomas C. Kupiec, PhD  Journal of Pain and Symptom Management  Volume 28, Issue 6, Pages (December 2004) DOI: /j.jpainsymman Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

2 Figure 1 Morphine sulfate, bupivacaine hydrochloride, and clonidine hydrochloride concentrations in the samples stored at 4°C over a 90-day period. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

3 Figure 2 Morphine sulfate, bupivacaine hydrochloride, and clonidine hydrochloride concentrations in the samples stored at 37°C over a 90-day period. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

4 Figure 3 Morphine sulfate reservoir and catheter concentrations vs. time. Reservoir concentrations are indicated by the bold black line for 0, 30, 60, and 90-day time intervals. Catheter concentrations are indicated by the black dotted line for the same time points. Bold black lines indicate ± 10% of the initial reservoir concentration. Black dotted lines indicate ± 10% of the initial catheter concentration. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

5 Figure 4 Bupivacaine hydrochloride reservoir and catheter concentrations vs. time. Reservoir concentrations are indicated by the bold black line for 0, 30, 60, and 90-day time intervals. Catheter concentrations are indicated by the black dotted line for the same time points. Bold black lines indicate ± 10% of the initial reservoir concentration. Black dotted lines indicate ± 10% of the initial catheter concentration. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

6 Figure 5 Clonidine hydrochloride reservoir and catheter concentrations vs. time. Reservoir concentrations are indicated by the bold black line for 0, 30, 60, and 90-day time intervals. Catheter concentrations are indicated by the black dotted line for the same time points. Bold black lines indicate ± 10% of the initial reservoir concentration. Black dotted lines indicate ± 10% of the initial catheter concentration. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions


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