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Coping with Loss: Cell Adaptation to Cytoskeleton Disruption

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Presentation on theme: "Coping with Loss: Cell Adaptation to Cytoskeleton Disruption"— Presentation transcript:

1 Coping with Loss: Cell Adaptation to Cytoskeleton Disruption
David J. McGarry, Michael F. Olson  Developmental Cell  Volume 39, Issue 1, Pages 3-4 (October 2016) DOI: /j.devcel Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Acute versus Sustained DOCK6 Depletion/Deletion
DOCK6 acts as a RAC1/CDC42 GEF under basal conditions. RNAi-mediated depletion of DOCK6 reduces RAC1/CDC42 activity, inducing cytoskeletal collapse and cell rounding. Cells adjust to sustained or complete DOCK6 loss by suppressing ISG15 expression, resulting in reduced ISGylation of IQGAP1 and subsequent restoration of CDC42/RAC1 activity. Developmental Cell  , 3-4DOI: ( /j.devcel ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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