1. Emerging Strategies for Treating Brain Metastases from Breast Cancer
David P. Kodack, Vasileios Askoxylakis, Gino B. Ferraro, Dai Fukumura, Rakesh K. Jain 
Cancer Cell 
Volume 27, Issue 2, Pages (February 2015)
DOI: /j.ccell
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Figure 1
Schematic of Notable Targets of BCBM Formation Identified in Preclinical Studies
Molecules are categorized based on the stage of the metastatic cascade in which they are involved. Brain-tropic circulating tumor cells (CTCs) may express a particular signature, such as EpCAM-/HER2+/EGFR+/HPSE+/Notch1+ (Zhang et al., 2013). While drug delivery into brain metastatic lesions is compromised by the blood-tumor barrier (BTB), the ease of access is greater than in the normal brain (with an intact BBB). Methods used to enhance drug delivery are also mentioned. Table 1 provides more detail on each target.
Cancer Cell  , DOI: ( /j.ccell )
Copyright © 2015 Elsevier Inc. Terms and Conditions