1. Keeley Choy
Bacteriophage

2. What is Bacteriophage?
A virus that infects and replicates within bacteria.
Phages.
One of the most common and diverse entities in biosphere.
Come in different shapes, but most with capsid and tail
Caudovirales: 95%

3. Replication Lytic Cycle Lysogenic Cycle
Brings about death of bacterial cell
Viral DNA takes over host cell functioning to produce its own DNA and proteins
Viral mRNA translated to produce coat and tails
Lysogenic Cycle
Temperate Infection
Viral DNA integrates with bacterial chromosome
Replicates during normal cell division

5. Phage Therapy
Therapeutic use of lytic bacteriophages to treat pathogenic bacterial infections
Alternative to antibiotics
Target specific
Harmless to host cell and other bacteria
Easy to develop new ones against resistence
Few side effects
Can treat salmonella
Only approved in Russia and Georgia

6. Other Roles Bacteriophage contamination in Fermentation
Bacteriophage T4 infects E. Coli
Bacteriophage causes toxic Cholera strains