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Thomas W. Wakefield, MD, Robert M

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1 Venous thrombosis prophylaxis by inflammatory inhibition without anticoagulation therapy 
Thomas W. Wakefield, MD, Robert M. Strieter, MD, Robert Schaub, PhD, Daniel D. Myers, DVM, Martin R. Prince, MD, PhD, Shirley K. Wrobleski, Frank J. Londy, Amy M. Kadell, Sandra L. Brown, Peter K. Henke, MD, Lazar J. Greenfield, MD  Journal of Vascular Surgery  Volume 31, Issue 2, Pages (February 2000) DOI: /S (00) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 A, Note proximal and distal balloons, right renal vein (RRV) and left renal vein (LRV) , and area of mid inferior vena cava (IVC; arrow) between (B) gray-scale ultrasound scan image showing thrombus (arrow) in mid IVC just after balloon removal in a control animal. Journal of Vascular Surgery  , DOI: ( /S (00) ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Experimental protocol. US , Ultrasound scanning; MRV, magnetic resonance venography; rPSGL-Ig , recombinant P-selection glycoprotein ligand-Ig. Journal of Vascular Surgery  , DOI: ( /S (00) ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Tissue Doppler scan imaging in (A) longitudinal and (B) transverse orientation on day 2 in a control animal. Yellow color of thrombus tail (wide arrows) indicates it is moving at different velocity than rest of thrombus in inferior vena cava (IVC). Smaller arrows and white line indicate IVC wall. In an animal treated with recombinant P-selection glycoprotein ligand-Ig, with tissue Doppler scan imaging in mid IVC in longitudinal orientation, no thrombus is noted just after balloon removal (C) and on day 2 (D).Small arrows indicate IVC wall. Journal of Vascular Surgery  , DOI: ( /S (00) ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 4 Percent of inferior vena cava (IVC) segments with positive results for thrombus at various locations. rPSGL-Ig, Recombinant P-selection glycoprotein ligand-Ig. Journal of Vascular Surgery  , DOI: ( /S (00) ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

6 Fig. 5 With gadolinium-enhanced magnetic resonance imaging, note increased peri–inferior vena cava (IVC) enhancement in a representative saline solution control as compared with a representative recombinant P-selectin glycoprotein ligand-Ig (rPSGL-Ig), animal at day 2 (A). Additional representative animals are shown at day 6 (B). In control animals, no T-1 shortened blood is present because of thrombus, and in animals treated with rPSGL-Ig, increased signal is seen within slow-flowing blood. Note that despite presence of small amount of intraluminal thrombus in rPSGL-Ig–treated animal at day 2, no peri-IVC enhancement is seen. Journal of Vascular Surgery  , DOI: ( /S (00) ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

7 Fig. 6 With gadolinium-enhanced magnetic resonance imaging, note increased enhancement around right iliac vein (RIV) thrombus in a representative saline solution control versus a representative animal treated with recombinant P-selection glycoprotein ligand-Ig (rPSGL-Ig) at day 2 (A) and day 6 (B). In the rPSGL-Ig animal at day 2, thrombus is noted, and at day 6, a patent RIV is shown. Journal of Vascular Surgery  , DOI: ( /S (00) ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

8 Fig. 7 With time-of-flight magnetic resonance imaging, lumen opens up much more rapidly over time in a representative animal treated with recombinant P-selection glycoprotein ligand-Ig (rPSGL-Ig; A ) as compared with a representative saline solution–treated control (B). Journal of Vascular Surgery  , DOI: ( /S (00) ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

9 Fig. 8 Percent changes in platelet counts between groups at 6 hours, at day 2, and at day 6. rPSGL-Ig, Recombinant P-selection glycoprotein ligand-Ig Journal of Vascular Surgery  , DOI: ( /S (00) ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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