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Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening  David A. Vorp, PhDa,b,c, Paul C. Lee, MDa, David.

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Presentation on theme: "Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening  David A. Vorp, PhDa,b,c, Paul C. Lee, MDa, David."— Presentation transcript:

1 Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening  David A. Vorp, PhDa,b,c, Paul C. Lee, MDa, David H.J. Wang, MSa,b, Michel S. Makaroun, MDa, Edwin M. Nemoto, PhDd, Satoshi Ogawa, MDe, Marshall W. Webster, MDa  Journal of Vascular Surgery  Volume 34, Issue 2, Pages (August 2001) DOI: /mva Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

2 Fig. 1 A, Comparison of in vivo PO2 measurements for AAA wall adjacent to thick ILT versus AAA wall adjacent to thin or no ILT. B, In vivo measurements demonstrate PO2 gradient through thickness of AAA containing thick ILT. Note: all measurements normalized to respective luminal PO2 value. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

3 Fig. 2 Representative sections demonstrate neovascularization in group I and group II AAA wall specimens and in nonaneurysmal control specimens. Capillaries are identified via positive staining for von Willebrand factor. Original magnification × 200. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

4 Fig. 3 Quantification of neovascularization in group I, group II, and nonaneurysmal control specimens. Significant difference was noted between both group I and group II specimens and controls, but not between group I and group II. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

5 Fig. 4 Representative H&E sections demonstrate inflammatory cells in group I and group II AAA wall specimens and in nonaneurysmal control specimens. Original magnification × 100. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

6 Fig. 5 Quantification of inflammation in group I, group II, and nonaneurysmal control specimens. Significant difference was noted among all groups. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

7 Fig. 6 Serial immunohistochemistry sections for group I (A and D), group II (B and E), and primary-delete negative control (C and F) specimens stained with antibodies to ORP and CD45 and counterstained with Hoescht (A-C), or stained with antibodies to CD45 alone (D-F). Hoescht-stained nuclei appear blue, whereas ORP-positive cells appear green and CD45-positive cells appear red. Long arrows indicate representative colocalization of ORP- and CD45-positive cells, whereas arrowheads indicate representative cells that are ORP-positive only. Unspecific signal in negative control (C and F) is likely due to autofluorescence of elastin in tissue sections. Original magnification × 100. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

8 Fig. 7 Western blot for 150-kDa ORP in two different (A and B) group I–group II pairs of AAA wall specimens, nonaneurysmal control (DON ), positive control of hypoxic macrophages (MPs ) in culture, and negative control of normoxic macrophages in culture. Molecular weight markers correspond to ovalbumin (46 kDa), bovine serum albumin (66 kDa), phosphorylase b (97.4 kDa), beta-galactosidase (116 kDa), and myosin (200 kDa). Greater signal was detected in both group I specimens as compared with their paired group II specimen, and also as compared with nonaneurysmal control specimen. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

9 Fig. 8 Comparison of tensile strength for group I versus group II specimens. Significant difference was noted by means of the paired t test. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

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