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Published byTuomas Majanlahti Modified over 6 years ago
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Treatment for Pancreatic Cancer: Current Therapy and Continued Progress
A. Craig Lockhart, Mace L. Rothenberg, Jordan D. Berlin Gastroenterology Volume 128, Issue 6, Pages (May 2005) DOI: /j.gastro Copyright © 2005 American Gastroenterological Association Terms and Conditions
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Figure 1 Simplified illustration of an endothelial cell depicting the VEGF receptor and signaling pathway with ligand interaction and receptor dimerization resulting in tyrosine kinase phosphorylation and activation of intracellular signaling pathways. The sites of action of anti-VEGF monoclonal antibodies and VEGF receptor, tyrosine kinase inhibitors are shown. *These agents are not discussed in the text. Gastroenterology , DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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Figure 2 Simplified illustration of a tumor cell depicting the EGFR axis and showing ligand interaction and receptor dimerization leading to tyrosine kinase phosphorylation and activation of intracellular signaling pathways that are important for tumor progression. The sites of action for anti-EGFR monoclonal antibodies and tyrosine kinase inhibitors are depicted. Gastroenterology , DOI: ( /j.gastro ) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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