1. (A) Diagram to illustrate increase in excitatory synaptic transmission onto excitatory dorsal horn neurons following CCI and reversal of these changes following GBP treatment.
(A) Diagram to illustrate increase in excitatory synaptic transmission onto excitatory dorsal horn neurons following CCI and reversal of these changes following GBP treatment. The inset shows the characteristic delay-firing pattern of excitatory neurons. Red arrows illustrate relative quantity of glutamate released onto control excitatory neurons, onto neurons in animals subject to CCI, and onto CCI neurons following treatment with GBP. The inset shows the characteristic delay-firing pattern of excitatory neurons. (B) Diagram to illustrate decrease in excitatory synaptic transmission onto inhibitory dorsal horn neurons following CCI and restoration of glutamate release following GBP treatment. The inset shows the characteristic tonic-firing pattern of inhibitory neurons. Red arrows illustrate relative quantity of glutamate released onto control-inhibitory neurons, onto neurons in animals subject to CCI, and onto CCI neurons following treatment with GBP.
Sascha R. A. Alles, and Peter A. Smith Pharmacol Rev 2018;70:
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