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Suppression of Spontaneous Dermatitis in NC/Nga Murine Model by PG102 Isolated from Actinidia arguta
Eun-Jin Park, Kyoung Chul Park, Haekwan Eo, Jangkyun Seo, Miwon Son, Kyu Han Kim, Yoon-Seok Chang, Sang-Heon Cho, Kyung- Up Min, Mirim Jin, Sunyoung Kim Journal of Investigative Dermatology Volume 127, Issue 5, Pages (May 2007) DOI: /sj.jid Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 Effects of PG102T and PG102E on the development of dermatitis in NC mice. (a) Dermatitis index, (b) scratching incidence, and (c) clinical features were assessed by the criteria described in Materials and Methods. Values are expressed as means±SEM of 8–10 animals. (a) i**: 9–14 weeks, ii**: 10–14 weeks, iii**: 9–10 weeks/*: 11–14 weeks, (b) i**ii**: 9–13 weeks, iii**: 9–10 weeks/*:12–13 weeks. *, P<0.05; **, P<0.01, vs DW-treated NC mice. Bar=(a) index, (b) sec. Journal of Investigative Dermatology , DOI: ( /sj.jid ) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 2 Effects of PG102T and PG102E on the plasma levels of IgE and IgG2a in NC mice. (a) The levels of IgE and (b) two IgG subtypes were measured in plasma obtained from animals at the age of 7, 10, 12, 14 weeks and 12 weeks, respectively. Values are expressed as mean±SEM of 8–10 animals. *P<0.05; **P<0.01, vs DW-treated NC mice. Bar=(a) μg/ml. Journal of Investigative Dermatology , DOI: ( /sj.jid ) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 3 Effects of PG102T and PG102E on the skin lesions in NC mice. (a–e) Skin biopsies of mice were stained with hematoxylin and eosin and (f–j) toluidine blue. The microscope original magnification is (a–e) × 100 and (f–j) × 400. In the protein samples from skin biopsies, the level of IL-4, IL-5, eotaxin, and (k) TARC was measured by ELISA. Values are expressed as mean±SEM of five animals. *P<0.05; **P<0.01, vs DW-treated NC mice. Journal of Investigative Dermatology , DOI: ( /sj.jid ) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions
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