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A CRISPR Connection between Chromatin Topology and Genetic Disorders

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Presentation on theme: "A CRISPR Connection between Chromatin Topology and Genetic Disorders"— Presentation transcript:

1 A CRISPR Connection between Chromatin Topology and Genetic Disorders
Bing Ren, Jesse R. Dixon  Cell  Volume 161, Issue 5, Pages (May 2015) DOI: /j.cell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Structural Variation and Pathological Rewiring of Genetic Regulatory Interactions A genetic locus that includes genes and enhancers relevant to mammalian limb formation (top) has undergone deletions and inversions in humans, causing altered promoter-enhancer interactions (middle) and three distinct malformation syndromes (bottom). Recapitulating these structural variations in mice indicates that disruption of the TAD boundary domain is a key component of rewired circuitry and a pathological phenotype. Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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