Presentation is loading. Please wait.

Presentation is loading. Please wait.

Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis  Chun Wei Li, PhD, Li Shi, MD, Ke Ke Zhang, MD, Tian.

Published byMeelis Markus Modified over 6 years ago

Similar presentations

Presentation on theme: "Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis  Chun Wei Li, PhD, Li Shi, MD, Ke Ke Zhang, MD, Tian."— Presentation transcript:

1 Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis 
Chun Wei Li, PhD, Li Shi, MD, Ke Ke Zhang, MD, Tian Ying Li, MD, Zhi Bin Lin, MD, Mei Kee Lim, BSc, Frank McKeon, PhD, Wa Xian, PhD, De Yun Wang, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 3, Pages e2 (March 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Expression of p63 and TAp73 protein determined by means of immunohistochemistry in the nasal mucosa of representative control subjects (A), GC-naive patients with NP (B), and GC-treated patients with NP (C). Original magnification ×400. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Quantitative determination of mRNA by means of real-time RT-PCR for p63 (A), p73 (B), and the 2 p73 isoforms TAp73 (C) and ΔNp73 (D) in tissues from GC-naive (-GC) patients with NP and control subjects. All target mRNA relative expression levels were given as ratios of GAPDH transcript levels in the same RNA sample. Box plots are shown with medians plus 5th to 95th percentile whiskers. Statistical analyses were performed with the Mann-Whiney 2-tailed test. P values were considered significant at less than .05. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Relationship between mRNA levels of p63 versus p73 (A), TAp73 (B), and ΔNp73 (C) and mRNA levels between TAp73 and ΔNp73 (D) in GC-naive patients with NP and control subjects. The correlation coefficient (r) was calculated by using Spearman rank analysis. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Quantitative determination of mRNA by means of real-time RT-PCR for p63 (A), p73 (B), and the 2 p73 isoforms TAp73 (C) and ΔNp73 (D) in GC-naive (-GC) and GC-treated (+GC) patients with NP. All target mRNA relative expression levels were given as ratios of GAPDH transcript levels in the same RNA sample. Connecting lines indicate data obtained in the same subject before and after GC treatment. Statistical analyses were performed with the Wilcoxon matched-pairs signed-rank test. P values were considered significant at less than .05. NS, Not significantly different. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 A list of known p63-related biological functions and diseases by using IPA. Fx, Functions and diseases. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis  Chun Wei Li, PhD, Li Shi, MD, Ke Ke Zhang, MD, Tian."

Similar presentations

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,
Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease  Merja T. Augustin, MD, Jorma Kokkonen, MD,

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease  Merja T. Augustin, MD, Jorma Kokkonen, MD,
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease  Merja T. Augustin, MD, Jorma Kokkonen, MD,

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease  Merja T. Augustin, MD, Jorma Kokkonen, MD,
Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,

Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,
Critical link between glycogen synthase kinase 3β and forkhead box P3 in patients with chronic rhinosinusitis with nasal polyps  Xingmei Wu, MD, Sihua.

Critical link between glycogen synthase kinase 3β and forkhead box P3 in patients with chronic rhinosinusitis with nasal polyps  Xingmei Wu, MD, Sihua.
Russell S. Traister, MD, PhD, Crystal E. Uvalle, BS, Gregory A

Russell S. Traister, MD, PhD, Crystal E. Uvalle, BS, Gregory A
Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy  Michael Kulis, PhD, Katie.

Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy  Michael Kulis, PhD, Katie.
Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,

Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3  Feng Lan, MD, Nan Zhang,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis  Hyun-Woo Shin, MD, PhD, Dong-Kyu Kim, MD, Min-Hyun Park, MD,

IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis  Hyun-Woo Shin, MD, PhD, Dong-Kyu Kim, MD, Min-Hyun Park, MD,
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.
Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese  Ping-Ping Cao, MD, Hua-Bin Li, MD, PhD, Bao-Feng.

Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese  Ping-Ping Cao, MD, Hua-Bin Li, MD, PhD, Bao-Feng.
Histamine H2 receptor stimulation upregulates TH2 chemokine CCL17 production in human M2a macrophages  Susanne Mommert, PhD, Karl Gregor, MD, Kristine.

Histamine H2 receptor stimulation upregulates TH2 chemokine CCL17 production in human M2a macrophages  Susanne Mommert, PhD, Karl Gregor, MD, Kristine.
Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum  Lianghua Bin, MD, PhD, Michael G. Edwards,

Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum  Lianghua Bin, MD, PhD, Michael G. Edwards,
Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment  Lennart M. Roesner, PhD, Petra Kienlin, Gabriele.

Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment  Lennart M. Roesner, PhD, Petra Kienlin, Gabriele.
Deficient glucocorticoid induction of anti-inflammatory genes in nasal polyp fibroblasts of asthmatic patients with and without aspirin intolerance  Laura.

Deficient glucocorticoid induction of anti-inflammatory genes in nasal polyp fibroblasts of asthmatic patients with and without aspirin intolerance  Laura.
Antti E. Seppo, PhD, Chloe A. Autran, MSc, Lars Bode, PhD, Kirsi M

Antti E. Seppo, PhD, Chloe A. Autran, MSc, Lars Bode, PhD, Kirsi M
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Similar presentations

Ads by Google