1. Chapter 14: Mutation & repair
Fig. 14-1

3. Dose-dependent induction of mutation by X-rays
Fig. 14-2

6. Fig. 14-3

7. Consequences of mutations on RNA and protein
Fig. 14-4

8. Normal keto tautomers
Standard base pairing
Fig. 14-5

9. Normal keto tautomers
Standard base pairing
Rare tautomers
Alternative base pairing
Fig & 6

10. Some analogs increase tautomeric shifts
Fig & 8

11. Alkylated bases have altered pairing possibilities
Fig. 14-9

12. Classic frameshift mutagens
Fig

13. Classic frameshift mutagens
Fig

14. UV-induced pyrimidine crosslinks
Fig

15. Potent carcinogen
Synthesized by fungus grown on peanuts
Fig & 14

16. Spontaneous mutations by deamination
Fig

17. Producing mutation “hotspots” at 5-methyl cytosine sites
Fig

18. Spontaneous mutation by replication of repeated nucleotide motifs
(frameshift mutations)
Fig

19. Resulting in clustered occurrence of frameshifts
Fig

20. DNA repair systems Direct repair of lesion General excision repair
Specific excision repair
ds-DNA end-joining
Post-replication repair

21. General types of nucleotide repair
Fig

22. Photo-activated thymine dimer repair
Fig

23. Depurination-activated
excision repair
(AP site repair)
Fig

24. Nucleotide excision repair
Fig

25. Repair of double-strand breaks: nonhomologous end-joining
(non-dividing cells)
Error-prone repair
Fig

26. Repair of double-strand breaks: homologous recombination
(dividing cells)
Error-free repair
Fig

27. Fig. 14-