1. The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer
Matthew R. Cooperberg, Nicholas Erho, June M. Chan, Felix Y. Feng, Nick Fishbane, Shuang G. Zhao, Jeffry P. Simko, Janet E. Cowan, Jonathan Lehrer, Mohammed Alshalalfa, Tyler Kolisnik, Jijumon Chelliserry, Jennifer Margrave, Maria Aranes, Marguerite du Plessis, Christine Buerki, Imelda Tenggara, Elai Davicioni, Peter R. Carroll 
European Urology 
Volume 74, Issue 4, Pages (October 2018)
DOI: /j.eururo
Copyright © 2018 European Association of Urology Terms and Conditions

2. Fig. 1
Heatmap of UCSF and GRID patients (n=1698) ordered by increasing AGR. The map indicates the following (from top to bottom): (1) the average genomic risk colored by the study the patient is part of, (2) Gleason score, (3) normalized scores for 18 prognostic signatures, and (4) hallmark gene set scores and their correlations to AGR indicated. The patients are broken up into quartiles based on the GRID reference set, and the number (%) of UCSF patients in each quartile is annotated. UCSF patients are associated with lower AGR; however, some UCSF patients are also found in the highest-risk quartile. AGR=average genomic risk; GRID=Decipher Genomic Resource Information Database; GS=Gleason score; UCSF=University of California, San Francisco. * p<0.05. ** p<0.01. *** p<0.001.
European Urology  , DOI: ( /j.eururo )
Copyright © 2018 European Association of Urology Terms and Conditions

3. Fig. 2
Heatmap of the UCSF patients (n=408) consensus clustered based on the expression score of 37 hallmark gene sets. The patients tend to cluster into three distinct groups, which are loosely associated with PAM50's basal, luminal A, and luminal B subtypes. CAPRA=Cancer of the Prostate Risk Assessment; PSA=prostate-specific antigen; UCSF=University of California, San Francisco.
European Urology  , DOI: ( /j.eururo )
Copyright © 2018 European Association of Urology Terms and Conditions

4. Fig. 3
Boxplot showing the AGR for each of the clusters from Figure 2. Patients in cluster 3 are found to be at the lowest AGR, while patients in cluster 2 are at the highest AGR (p<0.001). AGR=average genomic risk.
European Urology  , DOI: ( /j.eururo )
Copyright © 2018 European Association of Urology Terms and Conditions