1. New Opportunities: Harnessing Induced Pluripotency for Discovery in Diabetes and Metabolism 
Adrian Kee Keong Teo, Amy J. Wagers, Rohit N. Kulkarni 
Cell Metabolism 
Volume 18, Issue 6, Pages (December 2013)
DOI: /j.cmet
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2. Figure 1 Types of Diabetes and Metabolic Syndromes
The various types of diabetes and metabolic syndromes that can be modeled using induced pluripotent stem cells (iPSCs) include monogenic forms of diabetes, type 1 diabetes (T1D), and type 2 diabetes (T2D). T1D occurs as a result of immune attack by immune cells, such as macrophages and T cells, whereas T2D occurs as a result of insulin resistance in the pancreas, muscle, fat, and liver. Square represents male subjects, whereas circle represents female subjects. Filled symbols denote subjects with diabetes.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2013 Elsevier Inc. Terms and Conditions

3. Figure 2 Schematic of Derivation of hiPSCs from Patient Somatic Cells
Types of human somatic cells, which are relatively more accessible for reprogramming, include keratinocytes, dermal fibroblasts, adipocytes, and peripheral blood cells. Current reprogramming methods include the use of retroviruses, lentiviruses, plasmids, adenoviruses, Sendai viruses, transposons, protein, modified RNA, and miRNA.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2013 Elsevier Inc. Terms and Conditions

4. Figure 3
Differentiation of Diabetic hiPSCs into Various Cell Types for In Vitro Disease Modeling
Each type and/or source of diabetic hiPSCs can be differentiated into relevant cell types of interest for investigating disease mechanisms. Cell types of interest include pancreatic cells, cells involved in diabetic complications, and cells involved in insulin resistance.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2013 Elsevier Inc. Terms and Conditions