1. Elsevier’s New Biology Solution
Helping researchers understand the biology of disease.
Chris Cheadle PhD

2. DataFind

3. What dataset finding looks like today
Question: “I would like to rapidly review available gene expression data involving asthma studies for my gene of interest (e.g. CPA3)

4. Today finding information means scanning hundreds of dataset descriptions - one by one
Actual number of total entries for asthma gene expression in GEO
Today you will have to read the entire series of entries to find the dataset you might be interested in. You don’t want to miss anything important but it’s very likely that you will only be interested in a relatively small subset for further study. Filtering capabilities could be greatly enhanced using Elsevier text-mining capabilities.

5. Step 3 Extract data 1. Dataset Information Parsed
2. Retrieve All Datasets
4. Visualize Dataset Information
3. Annotate Datasets

6. Visualize Dataset Information
ELS DataFind
Asthma related gene expression datasets in GEO (by year)

7. Surface relevant information
Summary of all asthma-related gene expression datasets in GEO, organized by tissue type, organism, and number of studies.
Choose Selected Datasets

8. Choose Selected Datasets
ELS DataFind
Choose Selected Datasets
Advanced Filtering

9. Choose Selected Datasets
ELS DataFind (powered by Tableau™)
Choose Selected Datasets
Advanced Filtering w/ Highlighting

10. Choose Selected Datasets
ELS DataFind (powered by Tableau™)
Choose Selected Datasets
Advanced Filtering/Subset Selection

11. View Description of Selected Datasets
ELS DataFind (powered by Tableau™)
View Description of Selected Datasets
Advanced Filtering/Dataset Annotation

12. Search Unstructured Text
ELS DataFind (powered by Tableau™)
Keyword Search: “Smoking”
Search Unstructured Text

13. Data Find Entellect Preprocesssed Public Datasets Find Asthma
Retrieve All Datasets
Visualization & Selection
Data Analysis
Raw Datasets
Design experiment based on existing data
Asthma related gene expression datasets in GEO (by year)
Expert users may want to apply their own tools

14. Data Organization
Automatically organize selected data for rapid analysis
Return organized data to answer specific questions

15. ELS Data Import and Meta-analysis
CPA3 carboxypeptidase A3
This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients.

16. What researchers really want to do is ask…
“What’s my gene doing in other peoples data….?”
“Data Find” Benefits to Researchers:
Rapidly find out what is available in my area of interest
Rapidly acquire data in format for immediate analysis
Rapid acquisition of specific gene/protein results
Empowers both professional bioinformaticians and general biologists

17. Thank you and please feel free to take our survey: DataFind Survey.
Copyright© 2017 Elsevier B.V. All rights January 2017