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Solitary Fibrous Tumor Associated With Non-Islet Cell Tumor Hypoglycemia  Kotaro Kameyama, MD, Norihito Okumura, MD, Yujiro Kokado, MD, Kentaroh Miyoshi,

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Presentation on theme: "Solitary Fibrous Tumor Associated With Non-Islet Cell Tumor Hypoglycemia  Kotaro Kameyama, MD, Norihito Okumura, MD, Yujiro Kokado, MD, Kentaroh Miyoshi,"— Presentation transcript:

1 Solitary Fibrous Tumor Associated With Non-Islet Cell Tumor Hypoglycemia 
Kotaro Kameyama, MD, Norihito Okumura, MD, Yujiro Kokado, MD, Kentaroh Miyoshi, MD, Tomoaki Matsuoka, MD, Tatsuo Nakagawa, MD  The Annals of Thoracic Surgery  Volume 84, Issue 1, Pages (July 2007) DOI: /j.athoracsur Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 (A) Chest roentgenogram on admission showing a large mass in the left inferior lung field. (B) Coronal magnetic resonance imaging showing a well-defined multinodular mass. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 (A) The cut section of the resected tumor, which was believed to have originated from the visceral pleura of the left lower lobe. (B) Immunohistochemical staining of insulin-like growth factor II (IGF-II). Many tumor cells were positive for IGF-II antibody (original magnification, ×400). (C) Western immunoblot of serum IGF-II. Lane 1: recombinant IGF-II. Lane 2: our patient (preoperative). Lane 3: our patient (postoperative). Lane 4: another non-islet cell tumor hypoglycemia (NICTH) patient. Lane 5: normal subjects. Lane 6: another NICTH patient. Western immunoblot analysis shows that a large amount of high molecular weight IGF-II (20-kDa) was detected in the preoperative serum, whereas the amount of normal IGF-II (7.5-kDa) was increased in the postoperative serum. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Clinical course of plasma glucose level before and after surgery. Glucose supplementation of 10 g/hr was necessary for maintenance of the plasma glucose level during the preoperative fasting period. Shortly after tumor excision, the plasma glucose level was stable with glucose supplementation of 3.4 g/hr. (BS = blood sugar.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

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