1. Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−), gp130757F (757F) or gp130757F;Smad3−/− (757F;Smad3−/−) mice 21 days after challenge with bleomycin or saline.
Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−), gp130757F (757F) or gp130757F;Smad3−/− (757F;Smad3−/−) mice 21 days after challenge with bleomycin or saline. Images are representative of n = 3 mice. Scale bar = 500 µm (= 100 µm insets).B.Percent change in collagen content in lung homogenates between saline and bleomycin treated mice of the indicated genotypes 30 days after challenge. n ≥ 3 mice. The range of collagen levels between saline and bleomycin treated mice was 4.369–26.48 mg. Data are expressed as mean percentage change ± SEM, with *p < 0.05 using Bonferroni multiple comparisons test.C.Masson's trichrome stained section of lungs from wt (top) or Smad3−/− (bottom) mice 14 days after trans‐nasal delivery of control (left) or Ad‐mOsm virus (right). Images are representative of three mice. Scale bar = 500µm (= 100 µm insets).
Robert J. J. O'Donoghue et al. EMBO Mol Med. 2012;4:
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