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With Happyhour, Everyone's Under the Table

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1 With Happyhour, Everyone's Under the Table
Mark T. Palfreyman  Cell  Volume 137, Issue 5, Pages (May 2009) DOI: /j.cell Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 The Last Fly Left Standing
The hppy gene in flies encodes a Ste20 family kinase called Happyhour, which antagonizes the epidermal growth factor receptor/extracellular signal-regulated kinase (EGFR/ERK) pathway. Decreased Happyhour activity and increased signaling via the EGFR/ERK pathway (left) results in resistance to the sedating effects of ethanol, whereas increased Happyhour activity and decreased EGFR/ERK signaling results in hypersensitivity to ethanol (right). Cell  , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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