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Pharmacokinetics of paclitaxel administered by hyperthermic retrograde isolated lung perfusion techniques  David S. Schrump, MDa, Suoping Zhai, PhDb,

Published byRade Dolinšek Modified over 5 years ago

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Presentation on theme: "Pharmacokinetics of paclitaxel administered by hyperthermic retrograde isolated lung perfusion techniques  David S. Schrump, MDa, Suoping Zhai, PhDb,"— Presentation transcript:

1 Pharmacokinetics of paclitaxel administered by hyperthermic retrograde isolated lung perfusion techniques  David S. Schrump, MDa, Suoping Zhai, PhDb, Dao M. Nguyen, MDa, Todd S. Weiser, MDa, Bradley A. Fisher, BSd, Richard E. Terrill, BSd, Bernard M. Flynn, DVMd, Paul H. Duray, MDc, William D. Figg, PharmDb  The Journal of Thoracic and Cardiovascular Surgery  Volume 123, Issue 4, Pages (April 2002) DOI: /mtc Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 Paclitaxel concentration-time profile in perfusates. Doses are 2 mg (squares), 20 mg (diamonds), 40 mg (inverted triangles), 200 mg (triangles), and 800 mg (circles). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 Paclitaxel concentration-time profiles in lung tissues after perfusion and 1-hour intravenous paclitaxel infusion. Paclitaxel was administered by isolated lung perfusion at doses of 200 mg (filled squares) and 800 mg (filled circles) and intravenously at a dose of 200 mg (open squares). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 3 Representative sections of perfused and contralateral, nonperfused lung parenchyma (A and B, respectively) from a sheep receiving 800 mg of paclitaxel by means of isolated lung perfusion. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 4 Paclitaxel 50% inhibitory concentration (IC50) in cultured cancer lines under normothermic or hyperthermic conditions. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

6 Fig. 5 Effects of paclitaxel in cultured normal human bronchial epithelial cells under normothermic or hyperthermic conditions. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

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