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There's More Than One Way to Scale a Synapse

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1 There's More Than One Way to Scale a Synapse
Carlos D. Aizenman, Kara G. Pratt  Neuron  Volume 58, Issue 5, Pages (June 2008) DOI: /j.neuron Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Two Distinct Modes of Synaptic Scaling May Coexist in Neurons
In the first mode, rapid changes in spike rate trigger intracellular signaling pathways that ultimately regulate surface expression of AMPARs. In the second, long-term changes in network activity cause the release of diffusible factors, such as TNFα, which lead to scaling. β3 integrin-mediated regulation of AMPARs could be a point of convergence of these two pathways. Neuron  , DOI: ( /j.neuron ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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