1. Dynamics under the Telomeric Bridge
Sabrina Pisano, Eric Gilson, Marie-Josèphe Giraud-Panis 
Molecular Cell 
Volume 68, Issue 4, Pages (November 2017)
DOI: /j.molcel
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
An Allosteric Structural Transition in S. pombe Poz1 and Human TIN2 Telomeric Proteins Drives the Formation of the Shelterin Complex
Fission yeast and human shelterin subcomplexes that are either favored (upper panel) or disfavored (lower panel) by cooperative binding of subunits. For the sake of comparison with the human shelterin, the Taz1-Rap1 subcomplex is depicted as a single building block. The allosteric transition in Poz1 (TIN2) “conformational trigger,” induced by Tpz1 (TPP1) binding, increases Poz1 affinity for Rap1-Taz1 (TRF2), making the assembled protein bridge a more stable entity than individual subcomplexes (upper panel) and decreasing the probability for the existence of the subcomplexes depicted in the lower panels.
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2017 Elsevier Inc. Terms and Conditions