1. Age-Related Changes in Niche Cells Influence Hematopoietic Stem Cell Function 
Erin J. Oakley, Gary Van Zant 
Cell Stem Cell 
Volume 6, Issue 2, Pages (February 2010)
DOI: /j.stem
Copyright © 2010 Elsevier Inc. Terms and Conditions

2. Figure 1 Heterochronic Parabiosis Rejuvenates HSC Function
In aged mice (top), HSCs accumulate but exhibit skewed patterns of differentiation, favoring more production of myeloid cells at the expense of B lymphocytes. This effect is at least partially mediated by osteoblast niche cell production of IGF-1. When exposed to soluble factors from young mice (bottom), the impact of IGF-1 is overcome, HSC accumulation is dampened, and the ratio of B cell: myeloid cell production is recovered.
Cell Stem Cell 2010 6, 93-94DOI: ( /j.stem )
Copyright © 2010 Elsevier Inc. Terms and Conditions