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Shannon M. Kahan, Allan J. Zajac  Immunity 

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Presentation on theme: "Shannon M. Kahan, Allan J. Zajac  Immunity "— Presentation transcript:

1 A Stay of Execution: Type I Interferons Pardon T Cells from Death by Natural Killers 
Shannon M. Kahan, Allan J. Zajac  Immunity  Volume 40, Issue 6, Pages (June 2014) DOI: /j.immuni Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Type I IFN Signaling Protects Activated T Cells from NK-Cell-Mediated Death Type I IFN signals to antigen-activated T cells reduce the expression of NK cell activatory ligands and elevates the levels of inhibitory ligands, rendering the responding T cell resistant to NK cell attack. Without type I IFN signals, activated T cells can be targeted by perforin-dependent NK cell killing. Immunity  , DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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