1. Autcatalytic networks
Eörs Szathmáry
Collegium Budapest AND Eötvös University

2. Units of evolution multiplication heredity
variation
hereditary traits affecting survival and/or reproduction

3. Towards Systems Chemistry
Analysis of synthesis of coupled autocatalytic chemical systems
Origin of life and chemical technology

4. The formose ‘reaction’
formaldehyde
autocatalysis
glycolaldehyde
Butlerow, 1861

5. The reductive citric acid cycle

6. PEP carboxylase

7. The catalytic mechanism

8. Chemical evolution was a race between tar formation and life formation
Chemical networks
Tar
Life
What fraction of planets would end up with just tar?

9. Benner’s hypothetical ribo-organism (1999)
Membrane? Cofactors?

10. Another case: von Kiedrowski’s replicators

11. Von Kiedrowski’s replicator

12. Peptide replicator networks

13. The Soi reaction

14. Toward ribozyme self-replication

15. Towards a general polymerase

16. Anabolic autocatalysis I

17. Anabolic autocatalysis II

18. Towards replicable nanostructures

19. Gánti’s chemoton model (1974)
metabolism
template copying
membrane growth
ALL THREE SUBSYSTEMS ARE AUTOCATALYTIC

20. Pathways of supersystem evolution
metabolism
M B
boundary
M T
M B T
template
B T
INFRABIOLOGICAL SYSTEMS

21. Szostak’s vesicles