1. The reward system in addiction
Role in associative learning and craving

2. The reward system in addiction
Drugs:
Stimulants
Nicotine
Alcohol
Marihuana
Others
Nucleus Accumbens (NAc)
Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3),

3. The reward system in addiction
Drug = reward
Drugs:
Stimulants
Nicotine
Alcohol
Marihuana
Others
Nucleus Accumbens (NAc)
Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3),

4. Reward pathways: mesolimbic
Mesolimbic pathway
Nucleus Accumbens (NAc)
Ventral Tegmental Area
Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3),

5. Reward pathway: mesocortical
Prefrontal Cortex
Ventral Tegmental Area
Volkow, N. D., Wang, G. J.,et al(2015). Addiction Circuitry in the Human Brain. Focus, 13(3),

6. Associative learning and craving

7. Incentive-based learning
Reward
Incentive-based learning
Goal-directed behaviors
Nutt, D. & Nestor, L. (2013). Addiction. Oxford New York, NY: Oxford University Press.

8. Associative learning and conditioning
Reward
Associative learning and conditioning
Nutt, D. & Nestor, L. (2013). Addiction. Oxford New York, NY: Oxford University Press.

9. Associative learning and drug craving
Environmental stimuli
Reinforcer
Conditioned stimuli
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4),

10. Associative learning and drug craving
Neutral stimuli
Places
People
Mood state
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4),

11. Associative learning and drug craving
Neutral stimuli
Places
People
Mood state
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4),

12. Associative learning and drug craving
Conditioned stimuli
Places
People
Mood state
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4),

13. Associative learning and drug craving
Conditioned stimuli
Craving
Places
People
Mood state
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4),