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A Phase I/II Study of GTI-2040 Plus Docetaxel as Second-Line Treatment in Advanced Non-small Cell Lung Cancer: A Study of the PMH Phase II Consortium 

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Presentation on theme: "A Phase I/II Study of GTI-2040 Plus Docetaxel as Second-Line Treatment in Advanced Non-small Cell Lung Cancer: A Study of the PMH Phase II Consortium "— Presentation transcript:

1 A Phase I/II Study of GTI-2040 Plus Docetaxel as Second-Line Treatment in Advanced Non-small Cell Lung Cancer: A Study of the PMH Phase II Consortium  Natasha B. Leighl, MD, MMSc, FRCPC, Scott A. Laurie, MD, FRCPC, Xueyu E. Chen, MD, PhD, FRCPC, Peter Ellis, MD, PhD, FRCPC, Frances A. Shepherd, MD, FRCPC, Jennifer J. Knox, MD, FRCPC, Glenwood Goss, MD, Ronald L. Burkes, MD, FRCPC, Gregory R. Pond, MD, PhD, Christopher Dick, BSc, Yun Yen, PhD, James A. Zwiebel, MD, Malcolm J. Moore, MD, FRCPC  Journal of Thoracic Oncology  Volume 4, Issue 9, Pages (September 2009) DOI: /JTO.0b013e3181a949b2 Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Time to progression, non-small cell lung cancer (NSCLC) patients at RP2D (n = 18). RP2D, recommended phase 2 dose. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181a949b2) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Overall survival, non-small cell lung cancer (NSCLC) patients treated at RP2D. RP2D, recommended phase 2 dose. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181a949b2) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Steady state concentrations GTI-2040.10
Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181a949b2) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

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