1. Immunodeficiency Disorders
University of Jordan
School of Medicine
Department of Pathology, Microbiology and Forensic Medicine
Malik Sallam, MD, PhD

2. Primary Immunodeficiency (ID)

3. How to diagnose PID? Hx & PE. CBC & differential. Quantitative Igs.
Review of previous culture results.
Titers for administered vaccines.
Lymph enumeration using FCM.
Skin testing.
CH50, C3 & C4.
Phagocyte studies, NBT.
Enzyme studies.

4. Overview of the Primary ID

5. Defects of the B-Cell System X-Linked Bruton’s Agammaglobulinemia

6. Defects of the B-Cell System X-Linked Bruton’s Agammaglobulinemia

7. Defects of the B-Cell System Selective IgA Deficiency

8. Defects of the B-Cell System Common Variable Immunodeficiency

9. Defects of the T-Cell System DiGeorge Anomaly

10. Defects of the T-Cell System Hyper IgM Syndrome

11. Defects of Neutrophil Function Leukocyte Adhesion Deficiency

12. Complement Deficiencies

13. References
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Levinson W. Review of medical microbiology and immunology. 13th ed. New York: McGraw-Hill Medical; 2014.
Owen JA, Punt J, Stranford SA, Jones PP, Kuby J. Kuby immunology. 7th ed. New York: W.H. Freeman; 2013.
Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. 1st ed. Baltimore, MD: Lippincott Williams & Wilkins; 2008.
Nairn R, Helbert M. Immunology for medical students. 2nd ed. Philadelphia: Mosby; 2007.
Male D, Brostoff J, Roth DB, Roitt I. Immunology. 7th ed. Mosby/Elsevier; 2006.
Notarangelo LD. Primary immunodeficiencies. J Allergy Clin Immunol 2010,125:S
Modell V, Knaus M, Modell F, Roifman C, Orange J, Notarangelo LD. Global overview of primary immunodeficiencies: a report from Jeffrey Modell Centers worldwide focused on diagnosis, treatment, and discovery. Immunol Res 2014,60:
Reust CE. Evaluation of primary immunodeficiency disease in children. Am Fam Physician 2013,87:
Picard C, Al-Herz W, Bousfiha A, Casanova JL, Chatila T, Conley ME, et al. Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency J Clin Immunol 2015,35: