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Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40  Jose L. Gomez, MD, MS, Gina M. Crisafi,

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Presentation on theme: "Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40  Jose L. Gomez, MD, MS, Gina M. Crisafi,"— Presentation transcript:

1 Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40  Jose L. Gomez, MD, MS, Gina M. Crisafi, BS, Carole T. Holm, RN, Deborah A. Meyers, PhD, Gregory A. Hawkins, PhD, Eugene R. Bleecker, MD, Nizar Jarjour, MD, Lauren Cohn, MD, Geoffrey L. Chupp, MD  Journal of Allergy and Clinical Immunology  Volume 136, Issue 1, Pages e10 (July 2015) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Haplotype map for the CHI3L1 gene in subjects of EA from YCAAD and SARP. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 The A allele of rs in subjects of EA with asthma is associated with increased asthma severity (A), higher serum YKL-40 levels (B), and worse airflow obstruction (C). Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 The rs AA genotype in subjects of EA with asthma is associated with higher YKL-40 sputum levels. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E1 Haplotype maps for the CHI3L1 gene in subjects of AA in YCAAD and SARP (A), Utah residents with Northern and Western European Ancestry from the CEPH collection HapMap (B), and African ancestry in the Southwest United States HapMap (C). Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E2 Variation in the promoter SNP rs in the CHI3L1 gene and effect in YKL-40 protein levels in subjects of EA in YCAAD (A) and SARP (B). Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E3 rs and airflow obstruction in subjects of EA in YCAAD (A) and SARP (B). Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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