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The CARD15 (also known as NOD2) gene in Crohn's disease: Are there implications for current clinical practice?  Jean–Frédéric Colombel  Clinical Gastroenterology.

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Presentation on theme: "The CARD15 (also known as NOD2) gene in Crohn's disease: Are there implications for current clinical practice?  Jean–Frédéric Colombel  Clinical Gastroenterology."— Presentation transcript:

1 The CARD15 (also known as NOD2) gene in Crohn's disease: Are there implications for current clinical practice?  Jean–Frédéric Colombel  Clinical Gastroenterology and Hepatology  Volume 1, Issue 1, Pages 5-9 (January 2003) DOI: /jcgh Copyright © 2003 American Gastoenterological Association Terms and Conditions

2 Fig. 1 Outline of the innate-immune response to bacterial components. Reprinted with permission.29. Clinical Gastroenterology and Hepatology 2003 1, 5-9DOI: ( /jcgh ) Copyright © 2003 American Gastoenterological Association Terms and Conditions

3 Fig. 2 Representation of the NOD2/CARD15 domain structure and the position of the polymorphisms associated with Crohn's disease. The numbers represent the amino acid position. The C insertion at nucleotide 3020 causes a Leu 1007 Pro amino acid change followed by a stop codon. CARD, caspase recruitment domain; NBD, nucleotide binding domain; LRR, leucine rich repeat. Reprinted with permission.12 Clinical Gastroenterology and Hepatology 2003 1, 5-9DOI: ( /jcgh ) Copyright © 2003 American Gastoenterological Association Terms and Conditions


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