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Nat. Rev. Endocrinol. doi: /nrendo

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1 Nat. Rev. Endocrinol. doi:10.1038/nrendo.2016.169
Figure 5 Feedback loops between lipid metabolism and insulin resistance Figure 5 | Feedback loops between lipid metabolism and insulin resistance. Diet and activity can lead to obesity, which can lead to increased levels of fatty acids. These factors feed into multiple lipid metabolic pathways, which results in dysfunctional lipid metabolism and initiates multiple feedback loops through mitochondrial dysfunction, reactive oxygen species (ROS) production and inflammation. DAG, diacylglycerol, DHAP, dihydroxyacetone phosphate; FFA, free fatty acids; PC, phosphatidylcholine; PE, phosphatidylethanolamine. Meikle, P. J. & Summers, S. A. (2016) Sphingolipids and phospholipids in insulin resistance and related metabolic disorders Nat. Rev. Endocrinol. doi: /nrendo

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