1. Delta-toxin production deficiency in Staphylococcus aureus: a diagnostic marker of bone and joint infection chronicity linked with osteoblast invasion and biofilm formation 
F. Valour, J.-P. Rasigade, S. Trouillet-Assant, J. Gagnaire, A. Bouaziz, J. Karsenty, C. Lacour, M. Bes, S. Lustig, T. Bénet, C. Chidiac, J. Etienne, F. Vandenesch, T. Ferry, F. Laurent 
Clinical Microbiology and Infection 
Volume 21, Issue 6, Pages 568.e1-568.e11 (June 2015)
DOI: /j.cmi
Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

2. Fig. 1
Comparison of interactions between human osteoblasts and methicillin-susceptible Staphylococcus aureus (MSSA) isolates obtained from acute and chronic bone and joint infections (BJI). (a) Internalization rate of MSSA isolates within human osteoblasts; (b) Correlation between the internalization rate of MSSA clinical isolates and BJI evolution delay; (c) Cytotoxicity rate induced by human osteoblast infection by MSSA isolates; (d) proportion of phenotype switching to small-colony variants (SCVs).
Clinical Microbiology and Infection  , 568.e1-568.e11DOI: ( /j.cmi )
Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

3. Fig. 2
Comparison of biofilm formation by methicillin-susceptible Staphylococcus aureus (MSSA) isolates obtained from acute and chronic bone and joint infections (BJI).
Clinical Microbiology and Infection  , 568.e1-568.e11DOI: ( /j.cmi )
Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

4. Fig. 3
Comparison of the major methicillin-susceptible Staphylococcus aureus (MSSA) bone and joint infection (BJI) clones regarding their capacities to invade bone cells, induce cytotoxicity, convert to a small-colony variant (SCV) phenotype, and form biofilm. (a) Internalization rate of MSSA isolates within human osteoblasts; (b) cytotoxicity rate induced by human osteoblast infection by MSSA isolates; (c) proportion of phenotype switching to SCVs; (d) biofilm formation.
Clinical Microbiology and Infection  , 568.e1-568.e11DOI: ( /j.cmi )
Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

5. Fig. 4
Osteoblast invasion, cytotoxicity, and small-colony variant (SCV) intracellular emergence of methicillin-susceptible Staphylococcus aureus (MSSA) bone and joint infection (BJI) isolates regarding the bacterial production of delta-toxin. (a) Internalization rate of MSSA isolates within human osteoblasts; (b) cytotoxicity rate induced by human osteoblast infection with MSSA isolates; (c) proportion of phenotype switching to SCVs; (d) biofilm formation.
Clinical Microbiology and Infection  , 568.e1-568.e11DOI: ( /j.cmi )
Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions