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Hereditary angioedema: Safety of long-term stanozolol therapy

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1 Hereditary angioedema: Safety of long-term stanozolol therapy
David E. Sloane, MD, Chyh Woei Lee, MD, Albert L. Sheffer, MD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 3, Pages (September 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Stanozolol tapering protocol. The flowchart details the scheme by which the dosage of stanozolol was adjusted after the initiation of treatment and the control of symptoms. Patients who remained attack-free were followed closely and the dosage of stanozolol decreased as indicated (thin black arrows). If at any time a patient experienced a severe, acute HAE attack, the attack was treated with fresh frozen plasma and the stanozolol was increased to 4 mg by mouth every 6-8 hours (bold red arrows) until resolution of the attack. Thereafter, the tapering protocol was restarted. Milder attacks were managed with temporary increases in the dose (thin red arrows), and resumption of tapering after control was re-established. QD, daily; Q, every; PO, by mouth; QOD, every other day; Q3D, every 3rd day. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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